News & Media

TR-701 is Highly Differentiated on Key Attributes

Torezolid phosphate (TR-701) offers a number of important potential advantages over competing drugs, including efficacy, safety, convenience, and cost effectiveness. Trius has generated a substantial amount of data in support of these distinct attributes, which taken together with independent data generated by leading external experts and related publications in the field, underscores the unique profile and commercial significance of TR-701.

EFFICACY

Clinical and Clinical Microbiology Studies

Prokocimer et al. 2009. Safety and Efficacy of TR-701 in a Phase 2 Randomized, Double-Blind Study in Patients with Severe Complicated Skin and Skin Structure Infections (cSSSI). Posters of the 49th ICAAC (L1-335).

Torres et al. 2009. In vitro Activity of (Torezolid) TR-700 and Linezolid against Gram-positive Clinical Isolates from a Phase 2 Complicated Skin Clinical Trial. Posters of the 49th ICAAC (C1-1363a).

Nonclinical Studies

Louie, A and Drusano, G. 2009. In Vivo Pharmacodynamics of TR-701, a New Oxazolidinone Antibiotic, against Methicillin-Susceptible and Methicillin-Resistant Staphylococcusaureus Strains. Oral Presentations of the 19th ECCMID.

Louie, A and Drusano, G. 2009. Defining the Impact of Granulocytes (G) on the Kill of Methicillin-Resistant Staphylococcus aureus (MRSA) by the New Oxazolidinone Prodrug TR-701. Posters of the 49th ICAAC (A1-1935).

... see additional posters

Resistance

Jones et al. 2009. TR-700 in Vitro Activity Against and Resistance Mutation Frequencies Among Gram-positive Pathogens. J Antimicrob Chemother. 63:716-20.

Livermore et al. 2008. MICs Of TR-700 -the Active Moiety of the Novel Oxazolidinone Prodrug TR-701- for Linezolid-Susceptible and -Resistant Enterococci and Staphylococci. Posters of the 48th ICAAC (F-2060).

Livermore et al. 2009. Activity of Oxazolidinone TR-700 Against Linezolid-susceptible and -resistant Staphylococci and Enterococci. J Antimicrob Chemother. 63:713-715.

... see additional posters

SAFETY

Clinical Studies

Bien et al. 2009. The Safety of 21-Day Multiple Ascending Oral Doses of TR-701, a Novel Oxazolidinone Prodrug Antibiotic. Posters of the 19th ECCMID (P-1089).

Prokocimer et al. 2008. Hematological Effects of TR-701, Linezolid and Placebo Administered for 21 Days in Healthy Subjects. Posters of the 48th ICAAC (F1-2069a).

... see additional posters

COST EFFECTIVENESS

Zaoutis, T. 2009. Antibiotic Resistance: Who Will Pay the Bills? Clin Infect Dis. 49: 1185-1186.

Roberts et al. 2009. Hospital and Societal Costs of Antimicrobial‐Resistant Infections in a Chicago Teaching Hospital: Implications for Antibiotic Stewardship. Clin Infect Dis. 49: 1175-1184.

CONVENIENCE

Kardas, P. 2007. Comparison of Patient Compliance with Once-daily and Twice-daily Antibiotic Regimens in Respiratory Tract Infections: Results of a Randomized Trial. J Antimicrob Chemother 59(3):531-536.

Perez-Gorricho, B. and Ripoll, M. 2003. Does Short-course Antibiotic Therapy Better Meet Expectations? Int J Antimicrobial Agents. 21(3): 222-228.

OTHER RESOURCES

Emerging Resistance

Steinkraus et al. 2007. Vancomycin MIC Creep in Non-vancomycin-intermediate Staphylococcus aureus (VISA), Vancomycin-susceptible Clinical Methicillin-resistant S. aureus (MRSA) Blood Isolates From 2001–05. J Antimicrob Chemother 60(4): 788-794.

Tenover, F. and Moellering, R. 2007. The Rationale for Revising the Clinical and Laboratory Standards Institute Vancomycin Minimal Inhibitory Concentration Interpretive Criteria for Staphylococcus aureus. Clin Infect Dis. 44(9): 1208-1215.

Regulatory

European Medicines Agency. Clinical Development of New Agents to Treat Disease due to Mycobacterium Tuberculosis. January 20, 2010.